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  • For dabigatran, the comparative effects on vascular outcomes were dependent, in part, on the quality of adjusted-dose warfarin treatment. While anticoagulation control in the VHA appears to be at least as good as that found in clinical trials, the ROCKET-AF study had a mean TTR that was worse than typical the RE-LY study, the advantages of dabigatran were greater at sites with
  • Initiate warfarin on day 1 or 2 of parenteral anticoagulation therapy (eg, LMWH or unfractionated heparin) Overlap warfarin and parenteral anticoagulant for at least 5 days until desired INR (>2.0) maintained for 24 hours, then discontinue parenteral therapy; INR range and treatment duration. Maintain an …
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  • Liver cirrhosis is complicated by bleeding from portal hypertension but also by portal vein thrombosis (PVT). PVT occurs in approximately 20% to 50% of patients with cirrhosis, and is a warning sign for poor outcome. It is a challenge to treat patients with cirrhosis using anticoagulants, because of the perception that the coexistent coagulopathy could promote bleeding.
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Will you have Liver function test abnormal with Coumadin

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